Selected publications

• Titz B., Rajagopala S.V., Häuser R., Goll J., Wohlbold K., McKevitt M.T., Palzkill T. & Uetz P. (2008) The Binary Protein Interactome of Treponema pallidum - the Syphilis Spirochete. PloS ONE 3(5): e2292. doi:10.1371/journal.pone.0002292

• Rajagopala S.V., Titz B., Goll J., Parish J., McKevitt M.T., Palzkill T., Finley R.L. Jr. & Uetz P. (2007) The protein network of bacterial motility. Molecular Systems Biology 3: 128 (Faculty of 1000 MUST READ)

• Uetz, P. et al. (2006) Herpesviral Protein Networks and Their Interaction with the Human Proteome. Science 311: 239-242

• Sharan,R. et al. (2005) Conserved Patterns of Protein Interaction in Multiple Species. Proc. Natl. Acad. Sci. 102: 1974-1979

• Vollert, C.S. & Uetz, P. (2004) The PX domain protein interaction network in yeast. Molecular and Cellular Proteomics 3: 1053-1064.

• Uetz,P. et al. (2000) A comprehensive analysis of protein-protein interactions in Saccharomyces cerevisiae. Nature 403: 623-627

• Schwikowski,B., Uetz,P. & Fields,S. (2000) A network of interacting proteins in yeast. Nature Biotechnology 18 (12): 1257-1261

All recent publications

Click title to open full-text pdf files. Click cover images open larger images. Or see list in PubMed.

2008

• Koegl, M. & Uetz, P. (2008) Improving yeast two-hybrid systems. Briefings in Functional Genomics and Proteomics 6(4):302-12

• Uetz P., Titz B. & Cagney G. (2008) Experimental methods for protein interaction identification and characterization. In: Przytycka, T. & Panchenko, A., Protein-protein interactions and networks: identification, characterization and prediction.

• Goll, J.; Rajagopala, S.V.; Shiau, S.C.; Wu, H.; Lamb, B.T. & Uetz, P. (2008) MPIDB: the microbial protein interaction database. Bioinformatics 24: 1743-1744

• Rajagopala SV, J Goll, NDD Gowda, KC Sunil, B Titz, A Mukherjee, SS Mary, N Raviswaran, CS Poojari, S Ramachandra, S Shtivelband, SM Blazie, J Hofmann, P Uetz (2008) MPI-LIT: A literature-curated dataset of microbial binary protein-protein interactions. Bioinformatics 24 (22): 2622–2627

• Ester, C. & Uetz, P. (2008) The FF domains of yeast U1 snRNP protein Prp40 mediate interactions with Luc7 and Snu71. BMC Biochemistry 9: 29

2007

Original Research

• Titz B., Häuser R., Engelbrecher A. & Uetz P. (2007) The Escherichia coli protein YjjG is a House-Cleaning Nucleotidase in vivo. FEMS Microbiology Letters, 270 (1): 49-57.

• Rajagopala S.V., Titz B., Goll J., Parish J., McKevitt M.T., Palzkill T., Finley R.L. Jr. & Uetz P. (2007) The protein network of bacterial motility. Molecular Systems Biology 3: 128

• Orchard S, Salwinski L, Kerrien S, Montecchi-Palazzi L, Oesterheld M, Stümpflen V, Ceol A, Chatr-aryamontri A, Armstrong J, Woollard P, Salama JJ, Moore S, Wojcik J, Bader GD, Vidal M, Cusick ME, Gerstein M, Gavin AC, Superti-Furga G, Greenblatt J, Bader J, Uetz P, Tyers M, Legrain P, Fields S, Mulder N, Gilson M, Niepmann M, Burgoon L, De Las Rivas J, Prieto C, Perreau VM, Hogue C, Mewes HW, Apweiler R, Xenarios I, Eisenberg D, Cesareni G, Hermjakob H. (2007) The minimum information required for reporting a molecular interaction experiment (MIMIx). Nat Biotechnol. 25 (8):894-8

Invited book chapters:

• Rajagopala S.V.; Titz B. & Uetz P. (2007) Array-based yeast two-hybrid screening for protein-protein interactions. In: Yeast Gene Analysis 2nd Edition. Methods in Microbiology Series, Vol 36, Edited by Mike Stark and Ian Stansfield, Elsevier, pp. 139-163.

• Goll J. & Uetz P. (2007) Analyzing protein interaction networks. In: T.Lengauer (ed.), Bioinformatics - From Genomes to Drugs, Vol. 3, VCH-Wiley, pp. 1121-1177.

2006

Original Research

• Uetz, P., Y.-A. Dong, C. Zeretzke, C. Atzler, A. Baiker, B. Berger, S.V. Rajagopala, M. Roupelieva, D. Rose, E. Fossum & J. Haas (2005) Herpesviral Protein Networks and Their Interaction with the Human Proteome. Science 311: 239-242

• Titz, B., Thomas, S., Rajagopala, S.V., Chiba, T., Ito, T. & Uetz, P. (2006) Transcriptional activators in yeast. Nucleic Acids Res. 34 (3): 955-967

• Titz, B., Rajagopala, S.V., Ester, C., Häuser, R. & Uetz, P. (2006) A novel conserved assembly factor of the bacterial flagellum. J. Bacteriol. 188: 7700-7706

Invited Reviews

• Goll, J. & Uetz, P. (2006) The elusive yeast interactome. Genome Biology 7 (214): 1-6

• Uetz, P. & Stagljar, I. (2006) The interactome of human EGF/ErbB receptors. Molecular Systems Biology, doi:10.1038/msb4100048.

• Uetz, P. & Pohl, E. (2006) Protein-Protein and Protein-DNA Interactions [proofs, 1.5 MB!]. In: Wink, M. (ed.) Introduction to Molecular Biotechnology, Wiley-VCH, pp. 365-386

• Uetz, P., Sinner, E.-K., Schubert, D., Urbanke, C. (2006) Protein-Protein-Wechselwirkungen: Das two-hybrid-System und andere Methoden. Kapitel 16 in Lottspeich, F. & Engels, J.W., Bioanalytik, 2. Aufl., Spektrum/Elsevier, pp. 373-404.

• Uetz, P. & Vollert, C.S. (2006) Protein-Protein Interactions. Encyclopedic Reference of Genomics and Proteomics in Molecular Medicine (ERGPMM), Springer Verlag, Part 16: 1548-1552

• Vollert, C.S. & Uetz, P. (2006) The Two-hybrid System. Encyclopedic Reference of Genomics and Proteomics in Molecular Medicine (ERGPMM), Springer Verlag, Part 20: 1945-1949.

2005

Original Research

• Uetz, P., Y.-A. Dong, C. Zeretzke, C. Atzler, A. Baiker, B. Berger, S.V. Rajagopala, M. Roupelieva, D. Rose, E. Fossum & J. Haas (2005) Herpesviral Protein Networks and Their Interaction with the Human Proteome. ScienceExpress (published online Dec. 8. 2005)

• Sharan,R., Suthram,S., Kelley,R.M., Kuhn,T., McCuine,S., Uetz,P. Sittler,T., Karp, R.M. and Ideker,T. (2005) Conserved Patterns of Protein Interaction in Multiple Species. Proc. Natl. Acad. Sci. 102: 1974-1979.

Invited Reviews

• Uetz, P. & Finley, R.L. Jr. (2005) From protein networks to biological systems. FEBS Lett., 579: 1821-1827.

• Serebriskii, I.; Golemis, E. & Uetz, P. (2005) The yeast two-hybrid system for detecting interacting proteins. In: Walker, J.M. (ed.) The Proteomics Handbook, Humana Press, Totowa (NJ), pp. 653-682.

• Uetz, P. & Grigoriev, A. (2005) The yeast interactome [2.9 MB!]. In Jorde, L.B., Little, P.F.R., Dunn, M.J. and Subramaniam, S. (Eds), Encyclopedia of Genetics, Genomics, Proteomics and Bioinformatics. John Wiley & Sons Ltd: Chichester, volume 5, pp. 2033-2051.

• Ideker,T. & Tan, K. & Uetz, P. (2005) Visualization and integration of protein-protein interactions. In: Golemis,E. (ed.) Protein-Protein Interactions - A Molecular Cloning Manual, 2nd ed. Cold Spring Harbor Laboratory Press, pp. 839-856.

related stuff:

McCook, A. (2005) The Human Interactome Falls into place. The Scientist 2005, 19 (15):14

Greener, M. (2005) From Worm to Fly, Y2H Takes Off. The Scientist 2005, 19 (15):18

2004

Original Research

• Vollert, C.S. & Uetz, P. (2004) The PX domain protein interaction network in yeast. Molecular and Cellular Proteomics 3: 1053-1064.

• Antoniacci, L.M., Kenna, M.A., Uetz, P., Fields, S. & Skibbens, R.V. (2004) The spindle pole body assembly component Mps3p/Nep98p functions in sister chromatid cohesion. J. Biol. Chem. 279: 49542-49550.

• Wilkinson, C.R.M., Dittmar, G.A.G.; Ohi, M.D., Uetz, P., Jones, N. and Finley, D. (2004) Ubiquitin-like Protein Hub1 is Required for pre-mRNA Splicing and Localization of an Essential Splicing Factor in Fission Yeast. Current Biology 14 (24): 2283-2288

Invited Reviews

• Uetz, P. & Pankratz, M. (2004) Protein interaction maps on the fly. Nature Biotechnology 22 (1): 43-44

• Titz, B., Schlesner, M. & Uetz, P. (2004) What do we learn from high-throughput protein interaction data and networks? Expert Reviews in Proteomics 1 (1): 89-99

• Uetz, P., Rajagopala, S.V., Dong, Y.-A. & Haas, J. (2004) From ORFeomes to protein interaction maps in viruses. Genome Res. 14: 2029-2033

• Uetz, P. & Pohl, E. (2004) Protein-Protein- und Protein-DNA-Interaktionen [1.8 MB!]. In: Wink, M. (ed.) Molekulare Biotechnologie, Wiley-VCH, pp. 385-407.

related stuff:

Silva, J., Stotzka, R., Ruiter, N.V. & Uetz, P. (2004) Computergestützte Auswertung von Protein-Interaktions-Screens. Informatik Aktuell (Springer Verlag).

Orgeldinger, S. (2004) Mad Max im Labyrinth der Proteine. Badische Neueste Nachrichten vom 20.8.2004, S. 18. [Original Layout].

2003

• Guo M, Aston C, Burchett SA, Dyke C, Fields S, Rajarao SJR, Uetz P, Wang Y, Young K & Dohlman HG (2003) The yeast G protein alpha subunit Gpa1 transmits a signal through a novel effector polyribosomal protein Scp160. Molecular Cell 12: 517-524.

related stuff:

• Hazbun, T.R. et al. (2003) Assigning function to yeast proteins by integration of technologies. Molecular Cell 12: 1353-1365 (note and data).

2002

• Burchett SA, Flanary P, Aston CW, Jiang L, Young KH, Uetz P, Fields S and Dohlman HG (2002) Regulation of Stress Response Signaling by the N-terminal DEP (dishevelled/ EGL-10/pleckstrin) domain of Sst2, a Regulator of G Protein Signaling in Saccharomyces cerevisiae. J. Biol. Chem. 277 (25): 22156-22167

• Uetz,P., Ideker,T. & Schwikowski,B. (2002) Visualization and integration of protein-protein interactions [ 1.4 MB]. In: Golemis,E. (ed.) Protein-Protein Interactions - A Molecular Cloning Manual. Cold Spring Harbor Laboratory Press, pp. 623-646

• Uetz,P. (2002) Protein-Protein-Interaktionen im Modell Hefe. Bioforum 25 (1-2): 11-13

• Uetz,P. (2002) Protein-Protein Interactions in Yeast [uncorrected proofs]. Bioforum International 6 (3): 157-159

• Uetz,P. (2002) Proteomik: Proteine im (Hefe-) Kontext. FZK-Nachrichten 34 (1): 55-60

related stuff:

Hot paper: A Tale of Two-Hybrid. The Scientist 16 (10): 38

Uetz, P. (2002) Ran an den Speck! - Pardon...die Leber. Laborjournal 9 (10): 46-47

ISI Essential Science Indicators: New Hot Paper comment

2001

• Tucker,C.L., Gera, J.F. & Uetz,P. (2001) Towards an understanding of complex protein interaction maps. Trends in Cell Biology 11 (23): 102-106

• Cagney,G. & Uetz,P. (2001) High-throughput two-hybrid screening using yeast arrays. Current Protocols in Protein Science 19.6: 1-13

• Cagney,G., Uetz,P. & Fields, S. (2001) Functional genomic analysis of the Saccharomyces cerevisiae 26S proteasome. Physiological Genomics 7: 27-34

• Uetz,P. (2001) Two-Hybrid Arrays. Current Opinion in Chemical Biology 6: 57-62 [published online on Dec. 19, 2001; in print in the February 2002 issue]

related stuff:

Interview with "Sciencegarden" (in German)

Vom Anatom zum Proteom. Biotechnologie-Agentur BW (920 kb pdf, in German)

Book review: Functional Genomics, TIBS 26 (10): 636-637