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The PX domain has only recently been shown to be a novel PI (phosphoinositide)-binding domain. PX domains have been originally identified as a common motif of about 120 amino acids in the subunits p40phox and p47phox of the neutrophil NADPH oxidase (Phox) complex. This domain is conserved from yeast to man and more than 400 domain family members have been annotated in sequence databases (e.g. SMART database: http://smart.embl-heidelberg.de/) |
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Crystal Structure of the yeast Vam7p PX domain |
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